Fri Jul 22 2022

69 articles - From Friday Jul 15 2022 to Friday Jul 22 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…

Ann Intern Med

Web Exclusive. Annals for Hospitalists Inpatient Notes - Understanding the 2021 Surviving Sepsis Campaign Guidelines Recommendations on Fluid Resuscitation in Sepsis.

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Meta-analysis

meta-analyses and systematic reviews

Lancet

Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis.

These results should serve evidence-based clinical practice. Funding UK National Institute for Health Research Oxford Health Biomedical Research Centre.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Intern Med

Comparing Racial Differences in Emphysema Prevalence Among Adults With Normal Spirometry: A Secondary Data Analysis of the CARDIA Lung Study.

Emphysema is often present before spirometry findings become abnormal, particularly among Black men. Reliance on spirometry alone to differentiate lung health from lung disease may result in the underrecognition of impaired respiratory health and exacerbate racial disparities. Primary funding source National Institutes of Health.

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How the Gender Wage Gap for Primary Care Physicians Differs by Compensation Approach : A Microsimulation Study.

The gender wage gap varied by compensation model, with capitation risk-adjusted for patient age and sex resulting in a smaller gap. Future models might better align with primary care effort and outcomes. Primary funding source None.

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Lancet

Long-term efficacy and safety of moderate-intensity statin with ezetimibe combination therapy versus high-intensity statin monotherapy in patients with atherosclerotic cardiovascular disease (RACING): a randomised, open-label, non-inferiority trial.

Interpretation Among patients with ASCVD, moderate-intensity statin with ezetimibe combination therapy was non-inferior to high-intensity statin monotherapy for the 3-year composite outcomes with a higher proportion of patients with LDL cholesterol concentrations of less than 70 mg/dL and lower intolerance-related drug discontinuation or dose reduction. Funding Hanmi Pharmaceutical.

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Population-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study 2020.

Stronger interventions, particularly those tailored towards younger individuals, are needed to reduce the substantial global health loss attributable to alcohol. Funding Bill & Melinda Gates Foundation.

Pubmed   Journal   ReadQx   PMC

N Engl J Med

Aflibercept Monotherapy or Bevacizumab First for Diabetic Macular Edema.

In this trial of treatment of moderate vision loss due to diabetic macular edema involving the center of the macula, we found no evidence of a significant difference in visual outcomes over a 2-year period between aflibercept monotherapy and treatment with bevacizumab first with a switch to aflibercept in the case of suboptimal response. (Funded by the National Institutes of Health; Protocol AC ClinicalTrials.gov number, NCT03321513.).

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Effectiveness of BNT162b2 Vaccine against Omicron in Children 5 to 11 Years of Age.

During a period when the omicron variant was predominant, BNT162b2 vaccination reduced the risks of SARS-CoV-2 infection and Covid-19-related hospitalization among children 5 to 11 years of age.

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Pembrolizumab plus Chemotherapy in Advanced Triple-Negative Breast Cancer.

Among patients with advanced triple-negative breast cancer whose tumors expressed PD-L1 with a CPS of 10 or more, the addition of pembrolizumab to chemotherapy resulted in significantly longer overall survival than chemotherapy alone. (Funded by Merck Sharp and Dohme; KEYNOTE-355 ClinicalTrials.gov number, NCT02819518.).

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Phase 1-2 Trial of AAVS3 Gene Therapy in Patients with Hemophilia B.

Sustained factor IX levels in the normal range were observed with low doses of FLT180a but necessitated immunosuppression with glucocorticoids with or without tacrolimus. (Funded by Freeline Therapeutics; ClinicalTrials.gov numbers, NCT03369444 and NCT03641703; EudraCT numbers, 2017-000852-24 and 2017-005080-40.).

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Lancet

Measuring the future of humanity for health.

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N Engl J Med

Audio Interview: A Look at the U.S. Government's Covid-19 Strategy.

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Evidence for Step Therapy in Diabetic Macular Edema.

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Obesity in Pregnancy.

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Pembrolizumab in the Treatment of Breast Cancer.

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Letters&Replies

Letters to the editors and authors’ replies

Lancet

A fair day's wage for a fair day's work.

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Academic exploitation.

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Challenges en route to polio eradication.

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No to paid peer review.

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Payment and progress in peer review.

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Perilous two-tier COVID-19 global vaccine roll-out.

Pubmed   Journal   ReadQx   PMC

Reforms to accelerated approval of new medicines: long overdue.

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SOS Brazil: democracy under attack.

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The prohibition of nuclear weapons: a public health priority.

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Tobacco company funding and conflict of interest.

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Urgent need to update NICE guidelines on imaging for transient ischaemic attack.

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N Engl J Med

Calorie Restriction with or without Time-Restricted Eating in Weight Loss.

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Calorie Restriction with or without Time-Restricted Eating in Weight Loss. Reply.

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Efficacy of Antibodies and Antiviral Drugs against Omicron BA.2.12.1, BA.4, and BA.5 Subvariants.

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Higher-Dose Primaquine to Prevent Relapse of Plasmodium vivax Malaria.

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Higher-Dose Primaquine to Prevent Relapse of Plasmodium vivax Malaria.

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Higher-Dose Primaquine to Prevent Relapse of Plasmodium vivax Malaria. Reply.

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Nirmatrelvir for Nonhospitalized Adults with Covid-19.

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Nirmatrelvir for Nonhospitalized Adults with Covid-19.

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Nirmatrelvir for Nonhospitalized Adults with Covid-19. Reply.

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Obesity-Associated GNAS Mutations and the Melanocortin Pathway.

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Obesity-Associated GNAS Mutations and the Melanocortin Pathway.

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Obesity-Associated GNAS Mutations and the Melanocortin Pathway.

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Obesity-Associated GNAS Mutations and the Melanocortin Pathway. Reply.

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Preeclampsia. Reply.

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Protection Associated with Previous SARS-CoV-2 Infection in Nicaragua.

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Others

all remaining publications eg case reports, images of the month, etc…

Ann Intern Med

A Legacy of Scientific Racism.

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A Legacy of Scientific Racism.

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Annals for Educators - July 2022.

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Annals for Hospitalists - July 2022.

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Black, Incarcerated, and Dying: Reflections on Racism and Inequities in Health Care.

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Healing Water.

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Leave My Soul Alone!

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Web Exclusive. Annals Consult Guys - Portal Vein Thrombosis: What Could Be the Cause?

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Web Exclusive. Annals On Call - 100th Episode.

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Lancet

Ad-hoc medical mission for refugees in the Ukraine-Russia war: from vision to practice.

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Climate change driving east Africa towards famine.

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Complex relationship between health and moderate alcohol use.

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Facial lymphoedema, viral warts, and myelodysplastic syndrome: the protean condition of GATA2 deficiency.

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Health workers as agents of change and curators of knowledge.

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Lowering LDL cholesterol in clinical practice: time for change?

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Mariana Mazzucato: leading a new type of economics.

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Navigating recovery: the healing power of patients' narratives.

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New HIV law welcomed in Argentina.

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Preparing for uncertainty: endemic paediatric viral illnesses after COVID-19 pandemic disruption.

Pubmed   Journal   ReadQx   PMC

The UK COVID-19 Inquiry must examine the foundations of pandemic decision making.

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The UN reports global asymmetries in population growth.

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We need to make sure telecommuting does not exacerbate gender disparity.

Pubmed   Journal   ReadQx   PMC

What is the right drug for insomnia disorder?

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N Engl J Med

Case 22-2022: A 34-Year-Old Woman with Cavitary Lung Lesions.

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Communicating Statistics on the Health Effects of Climate Change.

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Grieving in a Pandemic.

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Nonketotic Hyperglycemic Hemichorea.

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Retropharyngeal Abscess.

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